HSP90, clients and typical events in cancer (IMAGE)

Sichuan International Medical Exchange and Promotion Association

HSP90, clients and typical events in cancer

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HSP90 plays a central role in six major oncogenic pathways involving client proteins, including the JAK/STAT, SMAD, NF-κB, MAPK, PI3K/Akt, and Wnt/β-catenin signaling pathways. These pathways collectively drive processes such as cell proliferation, invasion, angiogenesis, and motility in cancer.

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