The Stopwatch Complex forms during an extended mitosis (IMAGE)

Okinawa Institute of Science and Technology (OIST) Graduate University

The Stopwatch Complex forms during an extended mitosis

Caption

During an extended mitosis PLK1 triggers the formation of a Mitotic Stopwatch Complex that stabilizes and activates the tumor suppressor p53. This complex accumulates during one or successive prolonged mitoses and ultimately causes cell arrest or cell death.

Credit

Meitinger et al., 2024

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License

CC BY

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