Mechanism of action of Mcf1 toxin. (IMAGE)
Caption
After binding of the toxin to as yet unknown receptors on the surface of the host cell, the toxin is endocytosed. Acidification of the endosome triggers a conformational change inside the 600 amino acid-long delivery region, which forms a pore and translocates the head region of the toxin inside the target cell. After translocation, a series of proteolysis reactions and cleavages, Mcf1 toxic payloads are released, which impair essential physiological pathways ultimately leading to cell death.
Credit
MPI of Molecular Physiology
Usage Restrictions
The image may only be used with appropriate caption or credit.
License
Original content