Schematic diagram of DHFR topology traversing and the resulting functional benefits (IMAGE)

Science China Press

Schematic diagram of DHFR topology traversing and the resulting functional benefits

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A single-domain protein catenane of DHFR was designed and directly synthesized in cellular, which raises the Tm by 6 oC relative to the linear control and also has improved aggregation resistance as well as enhanced thermal resilience.

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©Science China Press

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