How the process works (IMAGE)
Caption
For people interested in the science behind these findings: By comparing cell lysis from untreated and treated bacteria, it is possible to see which proteins have changed. The cell lysis contains ‘traffic light proteins’, i.e. proteins involved in various bacterial signalling pathways. By using beads coupled to kinase inhibitors, activated proteins can be selected for via an available ATP-binding site (green traffic light). This provides insight into which cellular processes are active or deactivated, and thus provides valuable information about a cell’s response to antibiotics.
Credit
Illustration: Amanda Holstad Singleton
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