Illustration of VCAM1-APOE signalling pathway for Alzheimers disease (IMAGE)

Hong Kong University of Science and Technology

Illustration of VCAM1-APOE signalling pathway for Alzheimers disease

Caption

The diagram illustrates the VCAM1-APOE signalling pathway as a potential therapeutic target for Alzheimer’s disease. Interleukin-33 (IL-33) (1) increases VCAM1 expression in microglia (2), which stimulates the attraction of microglia to APOE-associated amyloid-β (Aβ) deposition (3), leading to the clearance of Aβ in the brain (4).

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HKUST

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