The JAK/STAT pathway. (IMAGE)

First Hospital of Jilin University

The JAK/STAT pathway.

Caption

Distinct intracellular signalling pathways are mediated by the JAK family of tyrosine kinases. The JAK-STAT pathways use second messengers to convey extracellular information to the nucleus to affect target gene expression and cellular responses. Image created through the use of www.biorender.com. GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IL, interleukin, JAK, Janus kinase; STAT, signal transducer and activator of transcription; TYK, tyrosine kinase.

Credit

By Dr Aditi Kumar and Dr Philip J Smith

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CC BY-NC

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