The noncanonical Wnt/PCP pathway (IMAGE)
Caption
The noncanonical Wnt/PCP pathway. The binding of Wnt ligands leads to the phosphorylation of Dvl, which recruits Invs, Par6, and Smurf. Smurf ubiquitinates the inhibitory protein Prickle, targeting it for destruction. Dvl can then associate with DAAM, activating Rac1, profilin, and RhoA. Rac1 activates JNK, which phosphorylates c-Jun and CapZIP. c-Jun then goes to the nucleus to stimulate gene transcription. RhoA activates ROCK and DIA1, with the latter activating MRLC. CapZIP, MRLC, DIA1, and profilin all stimulate actin polymerization. Celsr1 stimulates Dvl due to Wnt binding like the Fz receptor. Wnt binding to the Vangl2 receptor causes dissociation of Prickle and Intu from Dvl, which can then bind to Invs. The illustration was inspired by and created in BioRender.
Credit
Kevin Qin, et al.
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CC BY-NC-ND