Fig. 1: Somatic L1 retrotranspositions in normal cells. (IMAGE)

Korea University College of Medicine

Fig. 1: Somatic L1 retrotranspositions in normal cells.

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a, Experimental design of the study. HSC, haematopoietic stem and progenitor cells. b, Proportion of clones with various numbers of soL1Rs across different cell types (number of clones shown in parentheses). c, Proportion of normal colorectal clones with various numbers of soL1Rs across 19 individuals (number of clones shown in parentheses). d, Linear regression of the average number of soL1Rs per clone on age in 19 individuals with normal colorectal clones. Vertical line crossing each dot indicates the range of soL1R burden per clone in each individual. Blue line represents the regression line, and shaded areas indicate its 95% confidence interval. Two outlier individuals (HC15 and HC06) are highlighted in red. e,f, Early clonal phylogenies of HC14 (e) and HC19 (f) reconstructed by somatic point mutation. Branch lengths are proportional to the numbers of somatic mutations, which are shown by numbers next to the branches. Early embryonic branches are coloured by variant allele fraction (VAF) of early embryonic mutations (EEMs) in the blood. The numbers of soL1Rs detected are shown in the filled circles at the tips of branches. Pie charts indicate the proportion of blood cells harbouring the EEM or soL1R. RT segment, retrotransposed segment. g, Normalized soL1R rates in various stages and cell types.

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