Schematic representation of NRF1-triggered activation of aggrephagy mediated by impaired proteasome activity (IMAGE)

Doshisha University

Schematic representation of NRF1-triggered activation of aggrephagy mediated by impaired proteasome activity

Caption

he ubiquitin‒proteasome system (UPS) and autophagy are protein degradation pathways essential for maintaining protein balance and regulation, or proteostasis (left panel). When proteasome activity decreases because of several reasons including chemical inhibitors and aging, the transcription factor NRF1 gets activated, leading to the upregulation of proteasome gene expression (“the proteasome bounce-back response;” middle panel). Furthermore, complete proteasome dysfunction activates NRF1-mediated aggrephagy, inducing the expression of the aggrephagy-related genes p62 and GABARAPL1 (right). These cellular responses help combat proteasome dysfunction by maintaining proteostasis.

Credit

Atsushi Hatanaka, Sota Nakada, Gen Matsumoto, Katsuya Satoh, Iori Aketa, Akira Watanabe, Tomoaki Hirakawa, Tadayuki Tsujita, Tsuyoshi Waku, and Akira Kobayashi Image Source Link to be added in the Image Credit Section of EA form: https://www.nature.com/articles/s41598-023-41492-9

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