Fluorescence image of p62-positive puncta obtained using a confocal laser microscope (IMAGE)

Doshisha University

Fluorescence image of p62-positive puncta obtained using a confocal laser microscope

Caption

NRF1 plays a critical role in the formation of p62-positive puncta, facilitating the aggregation of p62 proteins after proteasome inhibition. This process is crucial for the efficient clearance of damaged proteins through aggrephagy and helps maintain cellular protein quality.

Credit

Atsushi Hatanaka, Sota Nakada, Gen Matsumoto, Katsuya Satoh, Iori Aketa, Akira Watanabe, Tomoaki Hirakawa, Tadayuki Tsujita, Tsuyoshi Waku, and Akira Kobayashi Image Source Link to be added in the Image Credit Section of EA form: https://www.nature.com/articles/s41598-023-41492-9

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