Commonly prescribed medications for high blood pressure have unexpected side effects
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Updates every hour. Last Updated: 21-Apr-2025 19:08 ET (21-Apr-2025 23:08 GMT/UTC)
Henry Daniell of the School of Dental Medicine at the University of Pennsylvania and collaborators found that medications commonly prescribed for the treatment of hypertension have a negative impact on the same pathway they target to lower blood pressure. Daniell says that when trying to lower blood pressure “you don’t want to inhibit a key cardioprotective enzyme, ACE2, and you don't want to increase the angiotensin II pool. And here we observed both.”
Jing Cai, PhD, of the Department of Neurosurgery at Massachusetts General Hospital, is the lead author of a paper published in Nature Communications, “Natural language processing models reveal neural dynamics of human conversation.”
An international research collaboration led by Rutgers University-New Brunswick scientists that examined microscopic blobs of protein found in human cells has discovered that some morph from an almost honey-like substance to a hard candy-like solid.
These mysterious droplets, known as biomolecular condensates, solidify when they carry a high proportion of the protein alpha-synuclein, the scientists reported in Science Advances. Clumps of alpha-synuclein are commonly found in the brain cells of people with Parkinson’s disease, a neurodegenerative brain disorder.