A 36-gene predictive score of anti-cancer drug resistance anticipates cancer therapy outcomes
Peer-Reviewed Publication
Updates every hour. Last Updated: 23-Apr-2025 13:08 ET (23-Apr-2025 17:08 GMT/UTC)
Using the established cancer cell databases GDSC, CTRP and COSMIC, researchers developed a combined score of the 36 genes most linked to drug resistance. This polygenic score showed superior correlation with relative resistance to various anti-cancer drugs compared to existing polygenic score, and it predicted the expression of genes linked to breast cancer resistance against tamoxifen.
Study results showed the highest detectable concentrations of heavy metals were lead, barium and chromium. All samples except for lead had less than or the same levels expected for an urban area.The median levels of lead detected in seven samples from play areas (400 mg/kg) and three samples from residential areas (1200 mg/kg) were four times the levels for Texas overall. And these likely were underestimated because they did not account for lead-based paint or automotive fuel.
It’s common knowledge that our brains—and, specifically, our brain cells—store memories. But a team of scientists has discovered that cells from other parts of the body also perform a memory function, opening new pathways for understanding how memory works and creating the potential to enhance learning and to treat memory-related afflictions.