image: Plain thoracic radiograph (A), maximum intensity projection of cone-beam CT image (B), and sagittal cone-beam CT reconstruction (C) show ethiodized oil (Lipiodol Ultra Fluid, Guerbet) extravasation (thick arrow, A-C) projected at left main bronchus 6 days after esophagectomy and thoracic duct ligation were performed. Extravasation is supplied by mediastinal collateral lymph vessels (thin arrows, A and B). view more
Credit: American Roentgen Ray Society (ARRS), <em>American Journal of Roentgenology</em> (AJR)
Leesburg, VA, June 14, 2021--According to ARRS' American Journal of Roentgenology (AJR), high-dose intranodal lymphangiography (INL) with ethiodized oil is a safe and effective procedure for treating high-output postsurgical chylothorax with chest tube removal in 83% of patients.
"To our knowledge," wrote corresponding author Geert Maleux of University Hospitals in Leuven, Belgium, "no data are available on the safety or potential beneficial effect of injecting higher doses of ethiodized oil to treat patients with refractory postoperative chylothorax."
All 18 patients (mean, 67 years; range, 43-76 years) the Belgian researchers reviewed between May 2015 and March 2019 had undergone INL with high doses of Guerbet's Lipiodol Ultra Fluid (mean, 75 mL; range, 40-140 mL). Eleven patients (61%) had previously undergone thoracic duct ligation, though seven (39%) had not, while lymphangiography confirmed lymphatic leak in 12 of 18 patients (67%).
For five of the 18 patients (28%), a second INL was performed within 11 days (range, 5-15 days)--due to increasing chest tube output after initiation of a medium-chain triglyceride-enriched diet--with three of the five (60%) showing complete resolution after the second session. Ultimately, removal of all chest tubes proved possible in 15 of 18 patients (83%) after a mean of 12 days (range, 1-25 days).
"Despite the doses being many times higher than the dose recommended by the manufacturer," the authors of this AJR article added, "no early or late clinically relevant complications, including symptomatic pulmonary or paradoxical embolism, were recorded for any of the patients."
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Founded in 1900, the American Roentgen Ray Society (ARRS) is the first and oldest radiological society in North America, dedicated to the advancement of medicine through the profession of radiology and its allied sciences. An international forum for progress in medical imaging since the discovery of the x-ray, ARRS maintains its mission of improving health through a community committed to advancing knowledge and skills with an annual scientific meeting, monthly publication of the peer-reviewed American Journal of Roentgenology (AJR), quarterly issues of InPractice magazine, AJR Live Webinars and Podcasts, topical symposia, print and online educational materials, as well as awarding scholarships via The Roentgen Fund®.
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American Journal of Roentgenology