Raised buildings may help reduce malaria transmission in Africa

There is growing evidence that house design can decrease the force of malaria infection.

The world's most deadly assassin is Africa's malaria mosquito: Anopheles gambiae. In 2019, the World Health Organisation estimated that malaria killed 386,000 people in sub-Saharan Africa, mainly children.

Whilst we think of the home as a sanctuary, in Africa, around 80% of the malaria bites occur indoors at night. Preventing mosquitoes from getting indoors is a simple way of protecting people from this often lethal disease.

As most mosquitoes fly low to the ground, a team of researchers led by Durham University wondered whether if, by raising a house, malaria mosquitoes would struggle to find the occupants.

The findings are published in the Journal of the Royal Society Interface.

Using four experimental houses, the researchers found that the number of female An. gambiae mosquitoes collected in the huts declined with increasing height, decreasing progressively as the hut's floor moved further from the ground.

Huts with floors 3 metres above the ground had 84 % fewer mosquitoes than those on the ground. Interestingly, if this reduction correlates to a similar reduction in malaria transmission, it would be comparable to that of an insecticide-treated net that can reduce malaria transmission by 40-90 %.

Research lead author Professor Steve Lindsay, from the Durham University Department of Biosciences, said: "Working with a team of architects and builders from the Royal Danish Academy - Architecture, Design and Conservation, we constructed four experimental houses in The Gambia, each of which could be raised or lowered. Each week, one hut was on the ground, whilst the bottoms of the other huts were at 1m, 2m and 3m.

"Each night two men slept under separate mosquito nets in each hut and mosquitoes were collected indoors using a light trap. We changed the height of each house weekly so that, at the end of the 40 night experiment, each hut had been at each of the four heights for 10 nights.

"After analysing the results, we found that increasing the height of a hut progressively reduced the number of mosquitoes entering the hut and we think there are two reasons for this.

"First, malaria mosquitoes have evolved to find humans on the ground. Second, at higher heights, the carbon dioxide odour plumes coming out of the huts are rapidly dispersed by the wind, so mosquitoes find it more difficult to find a person to bite.

Study lead, Durham University PhD Student Ms Majo Carrasco-Tenezaca said: "These findings have real-world implications for the growing population of sub-Saharan Africa where An. gambiae s.l. is the major vector of malaria and places where high temperatures reduce the use of bed nets.

"Raising houses off the ground, like any intervention, is not evolutionary proof, and over time, mosquitoes may adapt and feed higher off the ground than before.

"Nonetheless, we recommend elevating houses off the ground since they are likely to reduce mosquito biting and keep the occupants cooler at night, and therefore more likely to sleep under an insecticide-treated net at night."

The United Nations has projected that the population of sub-Saharan Africa will more than double between 2019 and 2050, and the region will become the world's most populated by 2062.

Coincident with the increasing growth rate, there has been an unprecedented improvement in the housing stock in sub-Saharan Africa. With an additional 1.05 billion people by 2050, there has never been a better time to make houses healthier for people.

###

This work was done in collaboration with the Medical Research Council's Unit The Gambia at the London School of Hygiene and Tropical Medicine, the Royal Danish Academy - Architecture, Design and Conservation, Denmark and the London School of Hygiene and Tropical Medicine.

Professor Steve Lindsay from Durham University Department of Biosciences is available for interview on Wednesday 26 May, Thursday 27 May and Friday 28 May 2021 and can be reached at s.w.lindsay@durham.ac.uk

Alternatively, please contact Durham University Marketing and Communications Office on communications.team@durham.ac.uk

Source information

DOI: https://doi.org/10.1098/rsif.2021.0256

Pictures available

Associated images of the "up and down houses" are available through this Dropbox link: https://www.dropbox.com/sh/skspudr3d0xuwar/AAC5WVv3tVnNkb6bn0gqSJAta?dl=0

Caption: The experimental huts on the edge of a Gambian village.

Credit: Steve Lindsay

Professor Steve Linday's profile: https://www.dur.ac.uk/research/directory/staff/?mode=staff&id=28

Department of Biosciences, Durham University: https://www.durham.ac.uk/departments/academic/biosciences/

Durham University is a globally outstanding centre of teaching and research based in historic Durham City in the UK.

We are a collegiate university committed to inspiring our people to do outstanding things at Durham and in the world.

We conduct boundary-breaking research that improves lives globally and we are ranked as a world top 100 university with an international reputation in research and education (QS World University Rankings 2021).

We are a member of the Russell Group of leading research-intensive UK universities and we are consistently ranked as a top 10 university in national league tables (Times and Sunday Times Good University Guide, Guardian University Guide and The Complete University Guide).

For more information about Durham University visit: http://www.durham.ac.uk/about/

END OF MEDIA RELEASE: Issued by Durham University Marketing and Communications Office - http://www.durham.ac.uk/news