News Release 

Leap forward for brain research

New product propels major human disease studies

Flinders University

Research News

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IMAGE: Flinders University senior research fellow Dr Cedric Bardy, who leads the Laboratory for Human Neurophysiology and Genetics based at the South Australian Health and Medical Research Institute (SAHMRI) in Adelaide,... view more 

Credit: Flinders Foundation

Pre-clinical research into deadly brain cancer, Parkinson's, dementia, epilepsy and other major psychiatric and neurological conditions can speed up with the global commercialisation of an advanced neuromedium, called BrainPhys™.

As outlined in Nature Communications, medical scientists in Australia and North America have given the BrainPhys™ Imaging (BPI) technology the thumbs-up, especially in vital work with live neurons in-vitro. With commercial partner STEMCELL Technologies, the laboratory medium was formulated by Flinders University senior research fellow Dr Cedric Bardy, who leads the Laboratory for Human Neurophysiology and Genetics based at the South Australian Health and Medical Research Institute (SAHMRI).

Dr Bardy's laboratory is working on better personalised medicine for brain disorders, including Parkinson's, brain cancer and a form of childhood dementia, using avatars of individual human brains.

The use of human pre-clinical models is vital to boost the success of clinical trials in neurology, he says.

"We developed this medium to support optimal neuronal function and viability in live imaging experiments using patient-derived brain cells in vitro, and this study shows that BrainPhys Imaging is superior in a wide range of fluorescent imaging settings," Dr Bardy says.

He says biotechnological innovations in the quest to find treatments and cures for these devastating diseases, which currently have few treatment options and often result in painful death, are extremely important.

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The article, BrainPhys neuronal medium optimized for imaging and optogenetics in vitro (2020), by M Zabolocki, K McCormack, M van den Hurk, B Milky, A Shoubridge, R Adams, J Tran, A Mahadevan-Jansen, P Reineck, J Thomas, MR Hutchinson, C Mak, A Añonuevo, LH Chew, AJ Hirst, VM Lee, E Knock and C Bardy has been published in Nature Communications
DOI: 10.1038/s41467-020-19275-x

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