Sophia Antipolis, 14 January 2020: Feeling excessively tired, devoid of energy, demoralised, and irritable? You may have burnout, a syndrome associated with a potentially deadly heart rhythm disturbance. That's the conclusion of a large study published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).1
"Vital exhaustion, commonly referred to as burnout syndrome, is typically caused by prolonged and profound stress at work or home," said study author Dr. Parveen K. Garg of the University of Southern California in Los Angeles. "It differs from depression, which is characterised by low mood, guilt, and poor self-esteem. The results of our study further establish the harm that can be caused in people who suffer from exhaustion that goes unchecked."
Atrial fibrillation is the most common form of heart arrhythmia. It is estimated that 17 million people in Europe and 10 million people in the US will have this condition by next year, increasing their risk for heart attack, stroke, and death. Yet, what causes atrial fibrillation is not fully understood.
Psychological distress has been suggested as a risk factor for atrial fibrillation, but previous studies showed mixed results. In addition, until now, the specific association between vital exhaustion and atrial fibrillation had not been evaluated.
The researchers in this study surveyed more than 11,000 individuals for the presence of vital exhaustion, anger, antidepressant use, and poor social support. They then followed them over a period of nearly 25 years for the development of atrial fibrillation.
Participants with the highest levels of vital exhaustion were at a 20% higher risk of developing atrial fibrillation over the course of follow-up compared to those with little to no evidence of vital exhaustion.
While further study is needed to better understand the observed relationship, Dr. Garg noted that two mechanisms are likely at play. "Vital exhaustion is associated with increased inflammation and heightened activation of the body's physiologic stress response," he said. "When these two things are chronically triggered that can have serious and damaging effects on the heart tissue, which could then eventually lead to the development of this arrhythmia."
No connections were found between anger, antidepressant use, or poor social support and development of atrial fibrillation. "The findings for anger and social support are consistent with prior research but two previous studies did find a significant association between antidepressant use and an increased risk of atrial fibrillation. Clearly, more work still needs to be done," said Dr. Garg.
Further research is also needed to identify concrete actions for doctors to help patients with exhaustion, said Dr. Garg.
He concluded: "It is already known that exhaustion increases one's risk for cardiovascular disease, including heart attack and stroke. We now report that it may also increase one's risk for developing atrial fibrillation, a potentially serious cardiac arrhythmia. The importance of avoiding exhaustion through careful attention to - and management of - personal stress levels as a way to help preserve overall cardiovascular health cannot be overstated."
Funding: The Atherosclerosis Risk in Communities study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services (contract numbers (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN26820 1700005I, HHSN268201700004I). This work was additionally supported by the American Heart Association (grant number 16EIA26410001 to Alonso) and the NHLBI (grant number K24HL148521).
1Garg PK, Claxton JS, Soliman EZ, et al. Associations of anger, vital exhaustion, anti-depressant use, and poor social ties with incident atrial fibrillation: The Atherosclerosis Risk in Communities Study. Eur J Prev Cardiol. 2020. doi:10.1177/2047487319897163.
The European Society of Cardiology brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people lead longer, healthier lives.
The European Journal of Preventive Cardiology is the world's leading preventive cardiology journal, playing a pivotal role in reducing the global burden of cardiovascular disease.