What The Study Did: A randomized clinical trial in Australia tested whether a dose of naloxone administered through the nose was as effective as the same dose delivered by injection to reverse opioid overdose as measured by the need for a rescue dose delivered by injection 10 minutes after the initial treatment. The study included 197 clients at a medically supervised injecting center in Sydney where eligible patients (18 or older with a history of injecting drug use) are allowed to inject drugs under the supervision of clinically trained staff who watch for signs of overdose.
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Authors: Paul Dietze, Ph.D., of the Burnet Institute in Melbourne, Australia, is the corresponding author.
(doi:10.1001/jamanetworkopen.2019.14977)
Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
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