Bottom Line: This study, called a systematic review and meta-analysis, combined the results of seven studies with 4.3 million participants to examine a potential association between bipolar disorder with a later diagnosis of Parkinson disease of unknown cause. The findings suggest that a previous diagnosis of bipolar disorder was associated with increased likelihood of a subsequent Parkinson disease diagnosis but subgroup analyses suggest the possibility of an overestimation of the magnitude of the associations. The main limitation of the study is analysis that suggests a greater likelihood of a Parkinson disease diagnosis in shorter studies which raises concerns over misdiagnosis.
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Authors: Joaquim J. Ferreira, M.D., Ph.D., Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, and coauthors.
(doi:10.1001/jamaneurol.2019.3446)
Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
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Media Advisory: To contact corresponding author Joaquim J. Ferreira, M.D., Ph.D., email joaquimjferreira@gmail.com. The full study is linked to this news release.
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Journal
JAMA Neurology