A commonly used medication, fluconazole, used to treat vaginal yeast infections, is linked to higher rates of miscarriage if used during pregnancy, found new research published in CMAJ (Canadian Medical Association Journal).
While topical treatments are first line for pregnant women with fungal infections, oral fluconazole is often used during pregnancy.
Researchers looked at data on 441 949 pregnancies from the Quebec Pregnancy Cohort between 1998 and 2015, linking to filled prescriptions listed in the Quebec Prescription Drug Insurance database. They found that taking oral fluconazole was linked to adverse outcomes.
"Our study shows that taking any dose of oral fluconazole while pregnant may be associated with a higher chance of miscarriage," says Dr. Anick Bérard, Université de Montréal, Montréal, Quebec. "Taking higher doses of fluconazole over 150 mg in early pregnancy may be linked to a higher chance of a newborn with a heart defect."
The study is consistent with other studies, although more research is needed as the study sizes are still small.
In a related commentary http://www.cmaj.ca/lookup/doi/10.1503/cmaj.190079, Drs. Vanessa Paquette and Chelsea Elwood, British Columbia Women's Hospital and Health Centre, Vancouver, BC, write, "The study re-emphasizes safe prescribing practices in pregnancy, which include confirming the correct diagnosis and then choosing the safest medication with the largest body of data in pregnancy at the lowest appropriate doses."
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"Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case-control studies" is published February 19, 2019.
Journal
Canadian Medical Association Journal