Researchers used computer modeling to study aspirin-receptor interactions and report the binding of aspirin to the peroxisome proliferator-activated receptor alpha (PPARα), a nuclear hormone receptor involved in fatty acid metabolism; in a mouse model of Alzheimer's disease, low-dose aspirin treatment activated PPARα and related biochemical pathways, resulting in improved hippocampal plasticity and memory, findings suggesting the therapeutic potential of aspirin in dementia-related illnesses.
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Article #18-02021: "Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory," by Dhruv Patel et al.
MEDIA CONTACT: Deb Song, Rush University Medical Center, Chicago, IL; tel: 312-942-0588; e-mail: <deb_song@rush.edu>
Journal
Proceedings of the National Academy of Sciences