News Release

Circadian rhythms and plasma proteome

Peer-Reviewed Publication

Proceedings of the National Academy of Sciences

A study examines the circadian rhythms of human plasma proteins. How the human plasma proteome varies in relation to sleep, circadian timing, and the time of day remains unclear. Christopher Depner, Kenneth Wright, and colleagues examined time-of-day patterns of human plasma proteins in six healthy male participants, around 26 years of age, during typical circadian-aligned conditions, with daytime food intake and nighttime sleep, and simulated night-shift-induced circadian misalignment, with daytime sleep and nighttime food intake. The authors analyzed 1,129 proteins and identified time-of-day patterns in 573 of the proteins, with 30 proteins exhibiting strong regulation by the circadian clock. The majority of the 30 proteins, which were associated with various cellular pathways, including extracellular matrix organization and tyrosine kinase signaling, peaked between 1400 and 2100 hours, regardless of sleep-wake timing. During circadian misalignment, time-of-day patterns and average abundances were altered for 127 proteins. The altered proteins were implicated in biological pathways involved in cancer, immune function, and metabolism. Moreover, circadian misalignment altered proteins involved in regulating glucose homeostasis and energy metabolism. The findings highlight potential effects of shift-work-induced circadian misalignment, according to the authors.

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Article #17-14813: "Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome," by Christopher M. Depner, Edward L. Melanson, Andrew W. McHill, and Kenneth P. Wright, Jr.

MEDIA CONTACT: Christopher M. Depner, University of Colorado Boulder, CO; tel: 303-735-6409, 303-735-1923; e-mail: <Christopher.depner@colorado.edu>; Kenneth P. Wright, Jr., University of Colorado Boulder, CO; tel: 303-735-6409, 303-735-1923; email: <kenneth.wright@colorado.edu>


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