News Release

Natural compound ameliorates multiple sclerosis in mouse model

Peer-Reviewed Publication

Proceedings of the National Academy of Sciences

Researchers report that bryostatin-1 (bryo-1)--a naturally occurring, brain-penetrating compound--attenuated neurologic deficits, even when administered late in the disease course, in mice with experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS); bryo-1, which has a favorable safety profile in humans, produced antiinflammatory effects in multiple immune cell types in vitro, suggesting a potential therapeutic role in MS treatment.

Article #17-19902: "Bryostatin-1 alleviates experimental multiple sclerosis," by Michael Kornberg et al.

MEDIA CONTACT: Paul M. Kim, Johns Hopkins University School of Medicine, Baltimore, MD; tel: 443-846-2676; e-mail: <pmkim@jhmi.edu>

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