Public Release: 

Novel drug delivery system has game-changing potential to reduce rates of HIV infection

An international collaboration announces preclinical development of a microarray patch delivery system for HIV pre-exposure prophylaxis

PATH

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IMAGE: Funding from the United States Agency for International Development (USAID), through the US President's Emergency Plan for AIDS Relief (PEPFAR), has made this work possible. view more 

Credit: USAID/PEPFAR/PATH

Seattle, WA, December 1, 2017--The United States Agency for International Development (USAID), through the U.S. President's Emergency Plan for AIDS Relief (PEPFAR), awarded PATH a three-year, $9.4 million grant to advance a needle-free microarray patch for delivery of HIV pre-exposure prophylaxis (PrEP). Microarray patches are a discreet, easy-to-use technology that contains an array of tiny projections that painlessly penetrate the top layer of skin to deliver a drug.

PATH, ViiV Healthcare, Queen's University Belfast, the Population Council, and LTS Lohmann Therapie-Systeme AG will combine their complementary expertise to develop a novel microarray patch for HIV PrEP in preparation for future clinical trials. The collaborators will engage with women and health care workers in Kenya, South Africa, and Uganda to design a microarray patch product that meets their needs.

The Joint United Nations Programme on HIV/AIDS (UNAIDS) estimates that 1.8 million people became infected with HIV in 2016, with the majority of infections occurring in young women in sub-Saharan Africa. Consistent use of daily oral HIV PrEP can help reduce the risk of infection, but compliance can be challenging. A discreet delivery mechanism that enables self-administration of a long-acting PrEP--with the potential to protect users for weeks or months at a time--could increase adherence for at-risk women and others.

"We are excited to work in close collaboration with both the public and private sectors to rapidly advance an alternative delivery technology to address a critically important global health need," says Darin Zehrung, team leader and program advisor at PATH for the Devices and Tools Program. "In the future, our vision is a self-administered microarray patch for PrEP product designed by, and for, the people who need it most."

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About PATH

PATH is the leader in global health innovation. An international nonprofit organization, PATH saves lives and improves health, especially among women and children. PATH accelerates innovation across five platforms--vaccines, drugs, diagnostics, devices, and system and service innovations--that harness our entrepreneurial insight, scientific and public health expertise, and passion for health equity. By mobilizing partners around the world, PATH takes innovation to scale, working alongside countries primarily in Africa and Asia to tackle their greatest health needs. With these key partners, PATH delivers measurable results that disrupt the cycle of poor health. Learn more at http://www.path.org.

About the United States Agency for International Development

The U.S. Agency for International Development (USAID) administers the U.S. foreign assistance program providing economic and humanitarian assistance in more than 80 countries worldwide. USAID is a key implementing agency of the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) and is responsible for over half of all PEPFAR programs with activities focused in 35 priority countries and regions, mainly in sub-Saharan Africa and Asia. Learn more about USAID's microbicides program at https://goo.gl/8QKB9s.

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