image: This picture shows a district in Salvador, the Brazilian metropolis where scientists have elucidated the Zika burden. view more
Credit: Ianei Carneiro
In 2016, news about the Zika virus in Brazil made the headlines in Europe for the first time. With approximately 65 million people affected, it is one of the largest epidemics in the last few years. The Olympics additionally fuelled fears that the virus could spread globally. When the first cases of newborns with microcephaly, i.e. malfor-mations of the brain, were observed in connection to Zika, it became apparent that further research was called for. The DZIF responded to this global challenge and, under the leadership of Jan Felix Drexler, Charité - Universitätsklinikum Berlin, initiated a German alliance project with Brazilian scientists, which investigates the pathogenesis and epidemiology of Zika.
Population immunity is giving the virus less and less latitude
"The spread of the Zika virus in northeastern Brazil has been so intense that the current Zika epidemic could soon be over," explains Drexler. People who have undergone Zika virus infections usually become immune against the virus. Consequently, fewer and fewer people can now contract Zika virus infections and subsequently serve as a source of the virus for mosquitoes. According to the authors of the study, "Outbreaks in the same region are therefore rather unlikely." The Zika virus is currently spreading from Brazil to the neighbouring countries but, according to Drexler, may gradually fade out on its own. However, to date it is still unclear as to whether the virus can hide in other animals to then cause new outbreaks in humans.
Laboratory-based data on the spread of the virus available for the first time
The study is the first laboratory-based epidemiological study since the start of the Zika epidemic. Samples from 910 humans in Salvador, northeast Brazil, were tested for Zika virus antibodies as well as for other viruses transmitted by mosquitoes--such as Chikungunya and dengue. The samples were obtained before, during and after the peak of the Zika outbreak. An infection rate of over 60 percent was observed in this metropolis. With mathematical modelling and sociodemographic data alongside the laboratory values, the scientists used a multidisciplinary approach to elucidate the speed of virus spread, areas most affected by Zika and the link to malformations in newborns.
Link between Zika and microcephaly
"The increased number of newborns with microcephaly observed during the Zika outbreak in Brazil is linked to Zika infection of the mother during early pregnancy," explains Drexler. Data from the Brazilian metropolis have confirmed this suspicion and, together with other studies, enable the researchers to estimate the absolute risk of microcephaly upon infection of the mother during pregnancy: approximately one out of 100 mothers infected during early pregnancy will bear a child with microcephaly.
Link between Zika and poverty
Analysis of geospatial data and socioeconomic status demonstrated a connection between the likelihood of Zika infection and increased poverty. "We can see that poorer regions are more severely affected by Zika," confirms Drexler. "Reasons for this can currently only be assumed." The scientists suspect that living conditions contribute to the situation. "Mosquitoes can more easily access these homes and people are more exposed." According to the authors of the study, these findings could be taken into consideration for developing future intervention measures, such as ensuring that people living in poorer regions have better access to protection against mos-quitoes. In addition, more targeted use of the potential vaccines and drugs that scientists are currently working on intensively could be planned.
Tackling global challenges jointly
The University of Cologne, Heidelberg University and the Heinrich Pette Institute in Hamburg were involved in the study through the ZIKApath project which was initiated by the DZIF. Further support was provided by the EU-funded project ZIKAlliance. The German researchers worked together closely with partners from the University of Salvador in Bahia, Brazil, as well as with partners from the University of Bonn Medical Centre, the Fraunhofer Institute in Leipzig, the London School of Hygiene & Tropical Health and Aix-Marseille University.
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Publication
Eduardo Martins Netto, Andres Moreira-Soto, Celia Pedroso, Christoph Höser, Sebas-tian Funk, Adam J. Kucharski, Alexandra Rockstroh, Beate M. Kümmerer, Gilmara Sou-za Sampaio, Estela Luz, Sara Nunes Vaz, Juarez Pereira Dias, Fernanda Anjos Bastos, Renata Cabral, Thomas Kistemann, Sebastian Ulbert, Xavier de Lamballerie, Thomas Jaenisch, Oliver J. Brady, Christian Drosten, Manoel Sarno, Carlos Brites, Jan Felix Drexler:
High Zika Virus Seroprevalence in Salvador, Northeastern Brazil Limits the Potential for Further Outbreaks. mBIO November 2017, 8 (6); doi: 10.1128/mBio.01390-17.
Contact
Prof Jan Felix DrexlerDZIF research field "Emerging Infections"
Charité - Universitätsmedizin Berlin
49-30-450-525461
felix.drexler@charite.de
Press contact
Karola Neubert and Janna Schmidt
DZIF Press Office
49-531-6181-1170-1154
presse@dzif.de
At the German Center for Infection Research (DZIF) approximately 500 scientists and doctors from 35 institutions throughout Germany jointly develop new approaches for the prevention, diagnosis and treatment of infectious diseases. The aim is to translate research results into clinical practice quickly and effectively. With this, the DZIF paves the way for developing new vaccines, diagnostics and drugs against infections. You can find more information at http://www.dzif.de.
Journal
mBio