For the first time, researchers have been able to identify effective treatments for patients with rare cancers by analyzing genes and proteins in their blood and tumors. In a study reported in The Oncologist, half the patients receiving these targeted treatments saw their rare cancers either stabilize, shrink or go into remission.
"To our knowledge, this is the first pilot study to use an individualized precision therapy approach in patients with rare tumors," says corresponding author Shumei Kato of the University of California (UC) San Diego Moores Cancer Center. "Our observations suggest that performing genomic analysis on patients with rare tumors can open the doors to new treatments for them."
Although individual rare cancers are uncommon, defined as having an incidence of less than 15 cases per 100,000 cancer cases each year, taken together they account for around 25% of all cancers, making them a serious healthcare issue. Nevertheless, individual rare cancers can be scientifically challenging to study and information about them is often derived from case reports or small-scale studies. They also generally lack treatments developed specifically for them. This makes rare cancers a challenge to manage in the clinic and, possibly due to this, patients with rare cancers have a lower five-year survival rate compared to those with more common cancers.
"Patients with rare tumors often have inadequate access to approved drugs or clinical trials," says senior author Razelle Kurzrock, also from the UC San Diego Moores Cancer Center. "There are large numbers of patients with rare cancers who need new treatment strategies."
Due to this unmet need for new treatments for patients with rare cancers, Kato, Kurzrock and their colleagues decided to investigate a precision medicine approach. Precision medicine takes advantage of recent technological and scientific advances in our understanding of the genetic changes that cause specific cancers. This has led scientists to realize that similar genetic mutations and alterations can be found in cancers that were previously thought quite distinct. So treatments developed for one type of cancer could prove equally effective at treating a completely different type of cancer, including rare cancers, if they target a genetic mutation common to both.
The researchers studied 40 patients who presented to the Rare Tumor Clinic at the UC San Diego Moores Cancer Center with various rare cancers, including sarcomas and cancers that could not be classified (known as cancers of unknown primary). They took blood and tumor samples from the patients, and then used several genomic and proteomic techniques to analyze the DNA and proteins in those samples to look for cancer-related mutations and alterations.
Based on the results of these genomic and proteomic analyses, Kato, Kurzrock and their colleagues were able to identify possibly effective treatments for half the patients in the study. These treatments included immunotherapy, which helps or encourages the immune system to attack cancer. Personalized treatments could not be found or were not appropriate for the other half of the patients for various reasons, such as because their cancers were already stable.
Among the 21 patients who received treatments targeted to their cancer, 52.4% either stabilized for at least six months or went into partial or complete remission. Furthermore, the 12 patients who had previously received conventional treatments for their rare cancers responded significantly better to the matched targeted treatments.
Based on their findings, Kato, Kurzrock and their colleagues have now adopted a precision medicine approach in their Rare Tumor Clinic and intend to conduct additional studies with more patients. "Further investigation is required to determine the usefulness and limitations of this approach," says Kato. "We hope to present further reports with a larger number of patients."
"The Kato et al article in The Oncologist goes a long way to highlight the impact of molecular testing of these rare tumors and the ability of precision medicine to find treatments that may already have been approved for the treatment of more common cancers and facilitate the care of patients with rare tumors in the molecular tumor board setting," said Jeffrey Ross, medical director of Foundation Medicine, a genomic profiling company based in Cambridge, MA, and a section editor of The Oncologist, who was not involved in the study.
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Additional Information
Full citation: "Rare Tumor Clinic: The UCSD Moores Cancer Center Experience with a Precision Therapy Approach" Shumei Kato, Kellie Kurasaki, Sadakatsu Ikeda, Razelle Kurzrock. The Oncologist. Published Online: October 16, 2017; DOI: 10.1634/theoncologist.2017-0199.
URL Upon Publication: https://doi.org/10.1634/theoncologist.2017-0199
Author Contact: To arrange an interview with Shumei Kato or Razelle Kurzrock, please contact Yadira Galindo, Communications and Media Relations Manager, UC San Diego Health (ygalindo@ucsd.edu; +1 858-249-0456).
About The Oncologist
Now celebrating its 22nd edition, this internationally peer-reviewed journal focuses on clear and concise interpretation addressing the multimodality diagnosis, treatment and quality of life of the cancer patient. Each issue is meant to impact the practice of oncology and to facilitate significant communication in the introduction of new medical treatments and technologies. The Oncologist is the official journal of the Society for Translational Oncology (STO).
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Established in 1983, AlphaMed Press, which has offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, is the publisher of three internationally renowned peer-reviewed journals. The Oncologist®, which is entering its 20th year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. STEM CELLS®, celebrating its 35th year, is the world's first journal devoted to this fast paced field of research. STEM CELLS Translational Medicine®, currently in its sixth year, is dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology.
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The Oncologist