Researchers report that administration of ALGERNON, a chemical compound that promotes the growth of neural stem cells (NSC) by inhibiting a kinase encoded in a chromosomal region implicated in Down syndrome (DS), to a mouse model of DS increased the number of newborn neurons, rescued NSC proliferation, and prevented abnormal brain morphology in embryos, with the resulting offspring exhibiting normal cognitive behavior, compared with untreated offspring with DS.
Article #17-04143: "Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice," by Akiko Nakano-Kobayashi et al.
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