Researchers have found that certain plant-derived products may help prevent and treat hepatitis B virus (HBV) infection. Proanthocyanidin (PAC) and its analogs, oolonghomobisflavanes, act by inhibiting viral entry into host cells.
The investigators noted that PAC was effective even against treatment-resistant HBV strains, and it augmented the ability of the antiviral drug tenofovir to interrupt HBV spread in human cells.
"PAC represents a specific inhibitor against HBV that is a less toxic plant-derived agent used as a dietary supplement," said Dr. Koichi Watashi, co-author of the Hepatology study.
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Journal
Hepatology