A recent review of the medical literature has identified 12 classes of drugs and 4 main pathophysiological mechanisms that can cause a side effect whereby small arteries that supply blood to the skin constrict in response to cold, limiting blood supply. The condition is called Raynaud's phenomenon.
"Beyond chemotherapies and beta-blockers, well known to induce Raynaud phenomenon, insights are currently emerging from a wide variety of drug classes through new pathophysiological pathways," said Dr. Charles Khouri, lead author of the British Journal of Clinical Pharmacology study.
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Journal
British Journal of Clinical Pharmacology