A challenging morning meeting or an interaction with an upset client at work may affect whether we go for that extra chocolate bar at lunch. In a study appearing August 5 in Neuron, researchers placed human volunteers in a similar food choice scenario to explore how stress can alter the brain to impair self-control when we're confronted with a choice.
"Our findings provide an important step towards understanding the interactions between stress and self-control in the human brain, with the effects of stress operating through multiple neural pathways," says lead author Silvia Maier, of the University of Zurich's Laboratory for Social and Neural Systems Research. "Self-control abilities are sensitive to perturbations at several points within this network, and optimal self-control requires a precise balance of input from multiple brain regions rather than a simple on/off switch." She emphasized that much work still remains, however, to fully understand the mechanisms involved.
In the study, 29 participants underwent a treatment known to induce moderate stress in the laboratory before they were asked to choose between two food options. An additional 22 participants did not undergo the treatment, which involved being observed and evaluated by the experimenter while immersing a hand in an ice water bath for 3 minutes, before choosing between the food options.
All of the participants who were selected for the study were making an effort to maintain a healthy lifestyle, so the study presented them with a conflict between eating a very tasty but unhealthy item and one that is healthy but less tasty.
The scientists found that when individuals chose between different food options after having experienced the stressful ice bath treatment, they overweighed food taste attributes and were more likely to choose an unhealthy food compared with people who were not stressed.
The effects of stress were also visible in the brain. Stressed participants' brains exhibited altered patterns of connectivity between regions including the amygdala, striatum, and the dorsolateral and ventromedial prefrontal cortex, essentially reducing individuals' ability to exercise self-control over food choices. Only some of these changes were associated with cortisol, a hormone commonly linked to stress.
The investigators say that their study indicates that even moderate levels of stress can impair self-control. "This is important because moderate stressors are more common than extreme events and will thus influence self-control choices more frequently and for a larger portion of the population," says senior author Todd Hare. "One interesting avenue for future research will be to determine whether some of the factors shown to protect against structural brain changes following severe stress--such as exercise and social support--can also buffer the effects of moderate stress on decision making," he adds.
There was also a good deal of variation in the degree to which stress affected individuals in the study, so it will be important to investigate why some people are more resilient than others.
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The study was supported by the Swiss National Science Foundation and the European Union Seventh Framework Programme.
Neuron, Maier et al.: "Acute Stress Impairs Self-Control in Goal-Directed Choice by Altering Multiple Functional Connections within the Brain's Decision Circuits" http://dx.doi.org/10.1016/j.neuron.2015.07.005
Neuron, published by Cell Press, is a bimonthly journal that has established itself as one of the most influential and relied upon journals in the field of neuroscience and one of the premier intellectual forums of the neuroscience community. It publishes interdisciplinary articles that integrate biophysical, cellular, developmental, and molecular approaches with a systems approach to sensory, motor, and higher-order cognitive functions. For more information, please visit http://www.cell.com/neuron. To receive media alerts for Neuron or other Cell Press journals, please contact press@cell.com.
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