image: This is Dr. Campbell, the study author. view more
Credit: Dr. Campbell
A new study reports that patients with knee osteoarthritis (OA) who have poor sleep habits display greater central sensitization--an amplification of clinical pain. Findings published in Arthritis Care & Research, a journal of the American College of Rheumatology (ACR), further show OA patients who catastrophize--consumed by thoughts of pain--had increased central sensitization that was associated with greater clinical pain.
OA--a degenerative joint disease that causes pain and swelling of joints in the hand, hips, or knee--affects nearly 27 million Americans 25 years of age and older according to the Centers for Disease Control and Prevention (CDC). Further evidence suggests that roughly one third of older adults have knee OA, a leading cause of pain and disability worldwide. Researchers believe that central sensitization, which is a hypersensitivity to pain, may contribute to the clinical pain amplification in OA.
"Our study is the largest and most comprehensive examination of the relationship between sleep disturbance, catastrophizing and central sensitization in knee OA," said lead author Claudia Campbell, Ph.D. from the Department of Psychiatry & Behavioral Sciences at Johns Hopkins University School of Medicine in Baltimore, Maryland.
The current case-controlled study included 208 participants who were categorized into four groups: OA patients with insomnia, OA patients with normal sleep habits, healthy controls with insomnia, and healthy controls without a pain syndrome and normal sleep. Seventy-two percent of the participants were female. Participants completed sleep assessments, psychological and pain evaluations, and sensory testing.
Results show that the subjects with knee OA and insomnia had the greatest degree of central sensitization compared to the controls. The team found patients with poor sleep and high catastrophizing scores reported increased levels of central sensitization. In turn, central sensitization was significantly associated with increased clinical pain.
Dr. Campbell concludes, "While no causal processes may be determined from this study, our data suggest that those with low sleep efficiency and higher catastrophizing have the greatest central sensitization. Understanding the intricate relationship between sleep, central sensitization, and catastrophizing has important clinical implications for treating those with chronic pain conditions such as knee OA."
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This study was supported by grants from National Institutes of Arthritis and Musculoskeletal and Skin Disease (R01 AR05487 & AR059410 [Smith]) and the National Institutes of Health (K23 NS070933, CMC).
This study is published in Arthritis Care & Research. Media wishing to receive a PDF of this article may contact sciencenewsroom@wiley.com.
Full citation: "Sleep, pain catastrophizing and central sensitization in knee osteoarthritis patients with and without insomnia." Claudia M. Campbell, Luis F. Buenaver, Patrick Finan, Sara C. Bounds, Mary Redding, Lea McCauley, Mercedes Robinson, Robert R. Edwards and Michael T. Smith. Arthritis Care and Research; Published Online: June 4, 2015 (DOI: 10.1002/acr.22609).
URL Upon Publication: http://doi.wiley.com/10.1002/acr.22609
Author Contact: To arrange an interview with Dr. Campbell please contact Vanessa McMains with Johns Hopkins University School of Medicine at vmcmain1@jhmi.edu.
About the Journal
Arthritis Care & Research is an official journal of the American College of Rheumatology (ACR), and the Association of Rheumatology Health Professionals (ARHP), a division of the College. Arthritis Care & Research is a peer-reviewed journal that publishes both original research and review articles that promote excellence in the clinical practice of rheumatology. Relevant to the care of individuals with arthritis and related disorders, major topics are evidence-based practice studies, clinical problems, practice guidelines, health care economics, health care policy, educational, social, and public health issues, and future trends in rheumatology practice. The journal is published by Wiley on behalf of the ACR. For more information, please visit the journal home page at http://wileyonlinelibrary.com/journal/acr.
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Arthritis Care & Research