Philadelphia, PA (November 14, 2014) -- Acute kidney injury occurs frequently in Ebola virus disease; however, providing hemodialysis to these patients was previously thought to be too risky because it involves large needles or catheters and potential contact with highly infectious blood. Clinicians recently accomplished the first known successful delivery of renal replacement therapy with subsequent recovery of kidney function in a patient with Ebola virus disease. Their protocol will be presented at ASN Kidney Week 2014 at the Pennsylvania Convention Center in Philadelphia, PA. It will also appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN) and be released on the JASN website on Friday, November 14th.
The report by Michael Connor, Jr, MD, Harold Franch, MD (Emory University School of Medicine), and their colleagues details the measures the clinicians took to maximize safety and minimize risk of secondary transmission of Ebola virus, including careful considerations to the types of equipment used and the protocols that clinical staff followed. None of the staff developed Ebola virus disease after a 21-day observation period, and no detectable Ebola virus genetic material was found in the patient's dialysis waste fluids.
"In our opinion, this report confirms that with adequate training, preparation, and adherence to safety protocols, renal replacement therapies can be provided safely and should be considered a viable option to provide advanced supportive care in patients with Ebola" said Dr. Connor.
In light of their success, the team has proposed a set of clinical practice guidelines for acute renal replacement therapy in Ebola virus disease.
"More than anything else, in our report, we found that extra training of our volunteer ICU nurses made success possible. We thank them for their bravery and commitment." said Dr. Franch. "Our case also shows that dialysis is not a death sentence for patients suffering from Ebola virus disease and recovery of kidney function is possible."
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Study co-authors include Colleen Kraft, MD, Aneesh Mehta, MD, Jay Varkey, MD, G. Marshall Lyon, MD, Ian Crozier, MD, Ute Ströher, PhD, and Bruce Ribner, MD.
Disclosures: The authors reported no financial disclosures.
The article, entitled "Successful Delivery of Renal Replacement Therapy in Ebola Virus Disease," will appear online at http://jasn.asnjournals.org/ on November 14, 2014.
ASN Kidney Week 2014, the largest nephrology meeting of its kind, will provide a forum for more than 13,000 professionals to discuss the latest findings in renal research and engage in educational sessions related to advances in the care of patients with kidney and related disorders. Kidney Week 2014 will take place November 11-16, 2014, in Philadelphia, PA.
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Founded in 1966, and with more than 15,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.