image: This is an intraoperative photograph of the rhesus monkey radial nerve repaired with a 2.5-cm allogeneic nerve containing autologous bone marrow stem cells. view more
Credit: Neural Regeneration Research
Current research on bone marrow stem cell transplantation and autologous or xenogenic nerve transplantation for peripheral nerve regeneration has mainly focused on the repair of peripheral nerve defects in rodents. Dr. Dong Wang and his team, First Affiliated Hospital of Sun Yat-sen University, China established a standardized experimental model of 2.5 cm-long radial nerve defects in rhesus monkeys and evaluated the effect of repair on peripheral nerve injury. The quality of nerve regeneration in the bone marrow stem cells-laden allografts was comparable to that achieved with autografts. The authors considered that they successfully established a simple model of radial nerve injury in the rhesus monkey to evaluate peripheral nerve repair. Related results were published in Neural Regeneration Research (Vol. 9, No. 10, 2014).
Article: " A simple model of radial nerve injury in the rhesus monkey to evaluate peripheral nerve repair," by Dong Wang, Xijun Huang, Guo Fu, Liqiang Gu, Xiaolin Liu, Honggang Wang, Jun Hu, Jianhua Yi, Xiaofeng Niu, Qingtang Zhu (Department of Orthopedics and Microsurgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China)
Wang D, Huang XJ, Fu G, Gu LQ, Liu XL, Wang HG, Hu J, Yi JH, Niu XF, Zhu QT. A simple model of radial nerve injury in the rhesus monkey to evaluate peripheral nerve repair. Neural Regen Res. 2014;9(10):1041-1046.
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Neural Regeneration Research