image: This shows the establishment of locations and voxels (diffusion weighted imaging) of the hippocampus (top ovals voxel) and substantia nigra (bottom rectangles voxel) in a female 76-year-old patient with psychosis associated with Parkinson's disease. view more
Credit: <i>Neural Regeneration Research</i>
Psychosis is a common non-motor symptom of Parkinson's disease whose pathogenesis remains poorly understood. Parkinson's disease in conjunction with psychosis has been shown to induce injury to extracorticospinal tracts as well as within some cortical areas. Jingmei Zhong and colleagues from First People's Hospital of Yunnan Province, China conducted a diffusion tensor imaging study in parkinson's disease patients with psychosis who did not receive antipsychotic treatment and those without psychosis, to determine whether the degree of white-matter fiber injury in brain regions associated with psychiatric symptoms is different from that which occurs in the extrapyramidal motor system. Results revealed that damage to the white-matter fibers in the brain regions associated with psychiatric symptoms were greater than that which occurs in the extrapyramidal motor system, which might explain why psychosis often occurs in Parkinson's disease patients. Using fractional anisotropy ratios of several brain regions, diffusion tensor imaging can be used to observe the relative degree of injury in brain regions associated with mental diseases, information that is valuable in the clinic and in scientific research. These findings were published in the Neural Regeneration Research (Vol. 8, No. 27, 2013).
Article: " Why psychosis is frequently associated with Parkinson's disease?," by Jingmei Zhong1, Shaoyuan Wu1, Ying Zhao2, Hui Chen1, Naiwei Zhao1, Kunwen Zheng1, Zhong Zhao1, Wenli Chen1, Bo Wang2, Kunhua Wu2 (1 Department of Neurology, First People's Hospital of Yunnan Province, Kunming 650032, Yunnan Province, China; 2 Department of Magnetic Resonance Imaging, First People's Hospital of Yunnan Province, Kunming 650032, Yunnan Province, China)
Zhong JM, Wu SY, Zhao Y, Chen H, Zhao NW, Zheng KW, Zhao Z, Chen WL, Wang B, Wu KH. Why psychosis is frequently associated with Parkinson's disease? Neural Regen Res. 2013;8(27):2548-2556.
Contact: Meng Zhao
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Journal
Neural Regeneration Research