image: This is a proton magnetic resonance spectroscopy of the hippocampus and thalamus of early growth response protein 3 gene-transfected rats. Choline (Cho; arrow represents Cho peak) content was increased in the left hippocampus of schizophrenic rats (A) compared with bilateral hippocampi of control group (B). view more
Credit: <i>Neural Regeneration Research</i>
Brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) are important genes and signaling pathways that are altered in schizophrenia. To date, no studies have reported magnetic resonance spectroscopy in a rat model of schi-zophrenia induced by early growth response protein 3 gene (Egr3) transfection. Prof. Guolin Ma and colleagues from China-Japan Friendship Hospital, China used multivoxel proton magnetic resonance spectroscopy to study neuronal metabolite content in rats transfected with the Egr3 gene as a putative model of schizophrenia. 3.0 T proton magnetic resonance spectroscopy of in vivo brain tissues showed metabolic abnormalities in hippocampal and thalamic neurons of growth response protein 3 transfected rats. These findings, published in the Neural Regeneration Research (Vol. 8, No. 26, 2013), provide imaging evidence that may be useful in the early diagnosis and pathogenesis of schizophrenia.
Article: " Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia," by Guolin Ma1, Tianbin Song2, Min Chen3, Yuan Fu3, Yong Xu4, Ensen Ma1, Wu Wang1,Jiang Du5, Ming Xionghuang6 (1 Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China; 2 Department of Radiology, Beijing Shunyi Hospital, Beijing 101300, China; 3 Department of Radiology, Beijing Hospital Affiliated to the Ministry of Public Health, Beijing 100730, China; 4 Department of Mental Health, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China; 5 Department of Radiology, University of California, San Diego, CA 92103-8226, USA; 6 Radiology Imaging Laboratory, Department of Radiology, University of California, San Diego, CA 92121, USA)
Ma GL, Song TB, Chen M, Fu Y, Xu Y, Ma ES, Wang W. Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia. Neural Regen Res. 2013;8(26):2415-2423.
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Journal
Neural Regeneration Research