The population of northeastern China has a high incidence of ischemic stroke. Previous studies have shown that intracranial large-artery atherosclerosis is one of the main causes of ischemic stroke, and that the mechanisms are related to inflammation and thrombosis of the affected arteries. A recent study by Lianqiu Min and colleagues from Liaoning Medical University observed the effects of atorvastatin treatment in 89 patients from northeastern China with acute ischemic stroke caused by intracranial large-artery atherosclerosis by measuring changes in the levels of markers of inflammation, thrombogenesis, and hyperlipidemia. The researchers found that atorvastatin treatment decreased the levels of markers of inflammation, thrombogenesis, and hyperlipidemia, suggesting that atorvastatin reduces inflammation and thrombogenesis independent of its lipid-lowering effects in patients with acute ischemic stroke caused by large-artery atherosclerosis. Most previous studies of patients with acute ischemic stroke caused by large-artery atherosclerosis focused mainly on measurement of the level of a single marker such as C-reactive protein, fibrinogen, or D-dimer. The study, reported by Lianqiu Min and colleagues in the Neural Regeneration Research (Vol. 8, No. 23, 2013), measured all three of these values to evaluate the effects of atorvastatin treatment, and expanded the range of atorvastatin available for the treatment of acute ischemic stroke.
Article: " Anti-inflammatory and anti-thrombogenic effects of atorvastatin in acute ischemic stroke," by Lianqiu Min1, Shuai Shao2, Xiaoning Wu1, Lin Cong3, Ping Liu4, Haiping Zhao4, Yumin Luo4 (1 Department of Neurology, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China; 2 Department of Neurology, Liaoyang Central Hospital, Liaoyang 111000, Liaoning Province, China;3 Department of Neurology, Fuxin No.2 People's Hospital, Fuxin 123000, Liaoning Province, China; 4 Research Institute of Cerebrovascular Diseases , Xuanwu Hospital of Capital Medical University, Beijing 100053, China)
Min LQ, Shao S, Wu XN, Cong L, Liu P, Zhao HP, Luo YM. Anti-inflammatory and anti-thrombogenic effects of atorvastatin in acute ischemic stroke. Neural Regen Res. 2013;8(23):2144-2154.
Contact: Meng Zhao
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Neural Regeneration Research
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Journal
Neural Regeneration Research