image: This shows caspase-3 expression (arrow) in the tumor tissue of glioma model rats after neural stem cell transplantation (immunohistochemical staining, x 400). view more
Credit: <i>Neural Regeneration Research</i>
Neural stem cells transplanted into tumor-bearing rats can hinder tumor cell growth and prolife-ration; however, the mechanism remains unclear. Abnormal activation of the Ras/Raf/Mek/Erk signaling cascade plays an important role in glioma. Inhibition of this aberrant activity could effectively hinder glioma cell proliferation and promote cell apoptosis. To investigate the mechanism of glioblastoma treatment by neural stem cell trans-plantation with respect to the Ras/Raf/Mek/Erk pathway, Hua Li and team from the 476 Hospital of Chinese PLA observed Raf-1, Erk and Bcl-2 protein expression as well as Caspase-3 protein expression. The researchers found that transplantation of neural stem cells could inhibit the abnormal activation of Ras/Raf/Mek/Erk signaling, thus promoting apoptosis and potentially treating glioma. These findings are published in the Neural Regeneration Research (Vol. 8, No. 19, 2013).
Article: " Apoptosis in glioma-bearing rats after neural stem cell transplantation " by Hua Li1, Zhenjun Chen1, Shaopeng Zhou2 (1 Department of Neurology, the 476 Hospital of Chinese PLA, Fuzhou 350002, Fujian Province, China; 2 Department of Anesthesiology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China)
Li H, Chen ZJ, Zhou SP. Apoptosis in glioma-bearing rats after neural stem cell transplantation. Neural Regen Res. 2013;8(19):1793-1802.
Contact: Meng Zhao eic@nrren.org 86-138-049-98773 Neural Regeneration Research http://www.nrronline.org/ Full text: http://www.sjzsyj.org:8080/Jweb_sjzs/CN/article/downloadArticleFile.do?attachType=PDF&id=650
Journal
Neural Regeneration Research