Preliminary studies by Dr. Zhihong Chen and colleagues from Chengde Medical College have shown that sericin might improve aberrant Akt signaling, decrease heme oxygenase-1 expression in the hippocampus and cerebral cortex, and reduce the apoptosis of hippocampal neurons in diabetic rats, thus protecting the nervous system. Recently, it is reported that the growth hormone/insulin-like growth factor 1 axis undergoes abnormal changes in diabetes mellitus, which aggravate the disease progression and trigger complications. To improve diabetes mellitus and its chronic complications, therefore, improvement of growth hormone/insulin-like growth factor 1 axis anomalies is one of the treatment strategies. A new study by the research group of Dr. Chen shows that sericin can significantly decrease the blood glucose levels of the diabetic rats, and alleviate diabetic hippocampal damage through improving disorders in the growth hormone/insulin-like growth factor 1. These results are published in the Neural Regeneration Research (Vol. 8, No. 19, 2013).
Article: " Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis," by Zhihong Chen1, Songhe Yang1, Yaqiang He1, Chengjun Song1, Yongping Liu2 (1 Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China; 2 Department of Biochemistry, Chengde Medical College, Chengde 067000, Hebei Province, China)
Chen ZH, Yang SH, He YQ, Song CJ, Liu YP. Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis. Neural Regen Res. 2013;8(19):1756-1764.
Contact:
Meng Zhao
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Neural Regeneration Research
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Journal
Neural Regeneration Research