image: Voxel-based morphometric analysis showed that the volume of the gray matter in the cingulate of the dominant hemisphere in relapsing-remitting multiple sclerosis patients was significantly reduced. view more
Credit: <i>Neural Regeneration Research</i>
In multiple sclerosis, gray matter atrophy is extensive, and cognitive deficits and mood disorders are frequently encountered. It has been conjectured that focal atrophy is associated with emotional decline. However, conventional MRI has revealed that the pathological characteristics cannot fully account for the mood disorders. Dr. Aiyu Lin and colleagues from the First Affiliated Hospital of Fujian Medical University used the voxel-based morphometry method to compare the difference in the clinical manifestations and imaging parameters of Chinese patients with multiple sclerosis and healthy controls. Furthermore, our study is the first to apply the Repeatable Battery for the Assessment of Neuropsychological Status scale in Chinese patients with relapsing-remitting multiple sclerosis to evaluate cognitive function. The researchers suggest that gray matter atrophy exists in relapsing-remitting multiple sclerosis, and the cingulate and frontal cortices of the dominant hemisphere are the most severely atrophic regions of the brain. Additionally, this atrophy is correlated with cognitive decline and emotional abnormalities. These findings are published in the Neural Regeneration Research (Vol. 8, No. 21, 2013).
Article: " Regional gray matter atrophy and neu-ropsychologcal problems in relapsing-remitting multiple sclerosis," by Aiyu Lin1, Fuyong Chen2, Fang Liu3, Zhiwen Li1, Ying Liu4, Shifang Lin1, Xiaoyi Wang2, Jiting Zhu1 (1 Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China; 2 Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China; 3 Department of Hyperbaric Oxygen Treatment, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China; 4 Department of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China)
Lin AY, Chen FY, Liu F, Li ZW, Liu Y, Lin SF, Wang XY, Zhu JT. Regional gray matter atrophy and neuropsychological problems in relapsing-remitting multiple sclerosis. Neural Regen Res. 2013;8(21):1958-1965.
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Journal
Neural Regeneration Research