image: Calpain 1 (arrow) was obviously increased in the mouse cochlea following cisplatin injection. view more
Credit: <i>Neural Regeneration Research</i>
Studies have shown that calpain participates in gentamicin-, neomycin- and kanamycin-induced inner ear cell apoptosis. Cisplatin has been shown to be an anticancer drug. However, cisplatin can lead to severe ototoxicity, induce cochlear cell apoptosis, and result in hearing decrease or loss, which limits the application of cisplatin in a clinical setting to a certain degree. A recent study by Liang Chang and colleagues from Jinzhou Central Hospital established a BALB/c mouse model of cisplatin-induced ototoxicity to detect the susceptibility to cisplatin-induced ototoxicity. Results from this study, published in the Neural Regeneration Research (Vol. 8, No. 21, 2013), suggest that calpain 1 and calpain 2 mediate cisplatin-induced ototoxicity in BALB/c mice; during this process, calpain 2 plays a leading role, which can provide evidence for clinical prevention and treatment of deafness caused by cisplatin-induced ototoxicity.
Article: " Calpain mediated cisplatin-induced ototoxicity in mice," by Liang Chang1, Aimei Wang2 (1 Party and Government Affairs Office, Jinzhou Central Hospital, Jinzhou 121001, Liaoning Province, China; 2 Department of Physiology, Liaoning Medical University, Jinzhou 121001, Liaoning Province, China)
Chang L, Wang AM. Calpain mediated cisplatin-induced ototoxicity in mice. Neural Regen Res. 2013;8(21):1995-2002.
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Neural Regeneration Research