image: S100 positive nerve fibers were visible in the scar tissue layer in the mechanical forces group at two weeks post-injury. view more
Credit: <i>Neural Regeneration Research</i>
Scars are prone to appear at high tension parts, such as the sternum, shoulder and back, which are serious clinical problems. Surgeons reduce scar formation through Z, W, V-Y flap variation and reducing blade tension, but its specific mechanism are still not very clear. Hu Xiao and colleagues from Shandong Provincial Hospital Affiliated to Shandong University verified that mechanical tension contributed to the formation of a hyperplastic scar in the back skin of rats, in conjunction with increases in both nerve density and nerve growth factor expression in the scar tissue. These experimental findings indicate that the cutaneous nervous system plays a role in hypertrophic scar formation caused by mechanical tension, which have been published in the Neural Regeneration Research (Vol. 8, No. 17, 2013).
Article: " Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression," by Hu Xiao, Dechang Wang, Ran Huo, Yibing Wang, Yongqiang Feng, Qiang Li (Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China)
Xiao H, Wang DC, Huo R, Wang YB, Feng YQ, Li Q. Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression. Neural Regen Res. 2013;8(17):1576-1581.
Contact: Meng Zhao
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Neural Regeneration Research
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Journal
Neural Regeneration Research