DNA altering enzyme is essential for blood cell development
The expression of specific genes is partially dictated by the way the DNA is packed into chromatin, a tightly packed combination of DNA and proteins known as histones. HDAC3 is a chromatin-modifying enzyme that regulates gene expression, chromatin structure, and genome instability and it has previously been shown to associate with the oncoproteins that drive leukemia and lymphoma. In this issue of the Journal of Clinical Investigation, Scott Hiebert and colleagues at Vanderbilt University examined the role of HDAC3 in the development of blood cells (hematopoiesis) by disrupting the expression of Hdac3. Loss of Hdac3 nearly eliminated all blood immune cells and caused mild anemia. Hiebert and colleagues observed that, in the absence of Hdac3, stem and progenitor cells, which give rise to blood cells, failed to grow normally. These studies identify a role for HDAC3 in stem cell functions and possibly bone marrow failure syndromes, in which the bone marrow fails to produce blood cells.
TITLE: HDAC3 is essential for DNA replication in hematopoietic progenitor cells
AUTHOR CONTACT:
Scott Hiebert
Vanderbilt University School of Medicine, Nashville, TN, USA
Phone: 615.936.3582; Fax: 615-936.1750; E-mail: scott.hiebert@vanderbilt.edu
View this article at: http://www.jci.org/articles/view/60806?key=51732e44292f61add1c3
Understanding the molecular mechanisms underlying Alzheimer's disease
The accumulation of amyloid-β (Aβ) in the brains of Alzheimer's disease (AD) patients is known to be associated with memory loss and neuronal degeneration, but the mechanism of Aβ pathogenesis is not fully understood. In this issue of the Journal of Clinical Investigation, researchers led by Yong-Keun Jung at Seoul National University demonstrate that Aβ binds to a cellular protein known as FCγRIIb. Greater levels of FCγRIIb were detected in the brains of AD patients. Binding of Aβ to FCγRIIb activated cell stress and death pathways. In a mouse model of AD, depletion of FCγRIIb ameliorated memory impairment. This study demonstrates that FCγRIIb plays a critical role in AD pathogenesis.
TITLE: FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease
AUTHOR CONTACT: Yong-Keun Jung
Seoul National University, Seoul, KOR
Phone: +82-2-880-4401; E-mail: ykjung@snu.ac.kr
View this article at: http://www.jci.org/articles/view/66827?key=09875f41f10ff79d5f1e
ALSO IN THIS ISSUE
TITLE: Transcription factor ATF3 links host adaptive response to breast cancer metastasis
AUTHOR CONTACT:
Tsonwin Hai
Ohio State University, Columbus, OH, USA
Phone: 614-292-2910; Fax: 614-292-5379; E-mail: tsonwin.hai@osumc.edu
View this article at: http://www.jci.org/articles/view/64410?key=6b62d754865e0751ec4b
TITLE: Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells
AUTHOR CONTACT:
Keigo Machida
Keck School of Medicine - University of Southern California, Los Angeles, CA, USA
Phone: 323-443-2692; E-mail: kmachida@usc.edu
View this article at: http://www.jci.org/articles/view/65859?key=bc2ba9aa926a1c23e6f9
TITLE: Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia
AUTHOR CONTACT:
Charles Mullighan
St. Jude Children's Research Hospital, Memphis, TN, USA
Phone: 901-595-3387; E-mail: Charles.Mullighan@STJUDE.ORG
View this article at: http://www.jci.org/articles/view/66203?key=2c6ee5b120aa14e3bc26
TITLE: DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity
AUTHOR CONTACT:
Joseph Callicott
NIMH, DIRP, NIH, Bethesda, MD, USA
Phone: 301-633-1436; Fax: 301-480-7795; E-mail: callicottj@mail.nih.gov
View this article at: http://www.jci.org/articles/view/67510?key=a8e4fb04dcd9321ca0af
TITLE: Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells
AUTHOR CONTACT:
Dario C. Altieri
The Wistar Institute, Philadelphia, PA, USA
Phone: 215-495-6970; E-mail: daltieri@wistar.org
View this article at: http://www.jci.org/articles/view/67841?key=227b86a3c20385625a79
TITLE: Type 2 alveolar cells are stem cells in adult lung
AUTHOR CONTACT:
Brigid Hogan
Duke medical center, Durham, NC, USA
Phone: 919 684 8085; E-mail: brigid.hogan@dm.duke.edu
View this article at: http://www.jci.org/articles/view/68782?key=a7b4317174a574a8de03
TITLE: Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis
AUTHOR CONTACT:
Shyam Biswal
Johns Hopkins University, Baltimore, MD, USA
Phone: 410-955-4728; E-mail: sbiswal@jhsph.edu
View this article at: http://www.jci.org/articles/view/66353?key=92077a338c57eb874662
Journal
Journal of Clinical Investigation