March 25, 2013, Shenzhen, China - In a collaborative study published online in Nature Genetics, researchers from Cardiff University, BGI, International Wildlife Consultants, Ltd., and Abu Dhabi Falcon Hospital, have completed the genome sequencing and analysis of two iconic falcons, the peregrine (Falco peregrinus) and saker (Falco cherrug). The work provides an invaluable resource for the deep understanding of the adaptive evolution in raptors and the genetic basis of their wide distribution.
Peregrine and saker falcons are widespread, and their unique morphological, physiological and behavioral adaptations make them successful hunters. The peregrine is renowned as the world's fastest animal, and the falcon is the national emblem of United Arab Emirate. In recent decades, peregrine and saker falcons have been listed as endangered due to rapid population declines caused by a wide range of factors including environmental change, overharvesting for falconry, habitat loss and bioaccumulation of pesticides (e.g. DDT, PCBs).
In this study, researchers focused on the evolutionary basis of predatory adaptations underlying peregrine and saker. They conducted whole genome sequencing and assembled the high quality ~1.2 Gb reference genomes for each falcon species. Phylogenic analysis suggested that the two falcon species might diverged 2.1 million years ago.
Comparing with chicken and zebra finch, researchers found the transposable element composition of falcons was most similar to that of zebra finch. Large segmental duplications in falcons are less frequent than that in chicken and zebra finch, and comprise less than 1% of both falcon genomes. They also found that a gene expansion in the olfactory receptor γ-c clade in chicken and zebra finch is not present in falcons, possibly reflecting their reliance on vision for locating prey.
Observing genome-wide rapid evolution for both falcons, chicken, zebra finch and turkey, researchers found that the nervous system, olfaction and sodium ion trans-port have evolved rapidly in falcons, and also the evolutionary novelties in beak development related genes of falcons and saker-unique arid-adaptation related genes.
Shenkai Pan, bioinformatics expert from BGI, said, "The two falcon genomes are the first predatory bird genome published. The data presented in this study will advance our understanding of the adaptive evolution of raptors as well as aid the conservation of endangered falcon species."
About BGI
BGI was founded in Beijing, China, in 1999 with the mission to become a premier scientific partner for the global research community. The goal of BGI is to make leading-edge genomic science highly accessible, which it achieves through its investment in infrastructure, leveraging the best available technology, economies of scale, and expert bioinformatics resources. BGI, which includes both private non-profit genomic research institutes and sequencing application commercial units, and its affiliates, BGI Americas, headquartered in Cambridge, MA, and BGI Europe, headquartered in Copenhagen, Denmark, have established partnerships and collaborations with leading academic and government research institutions as well as global biotechnology and pharmaceutical companies, supporting a variety of disease, agricultural, environmental, and related applications.
BGI has a proven track record of excellence, delivering results with high efficiency and accuracy for innovative, high-profile research: research that has generated over 200 publications in top-tier journals such as Nature and Science. BGI's many accomplishments include: sequencing one percent of the human genome for the International Human Genome Project, contributing 10 percent to the International Human HapMap Project, carrying out research to combat SARS and the 2011 German deadly E. coli outbreak, playing a key role in the Sino-British Chicken Genome Project, and completing the sequence of the rice genome, the silkworm genome, the first Asian diploid genome, the potato genome, and, more recently, the human Gut Metagenome, as well as a significant proportion of the genomes for the1000 Genomes Project.
For more information, please visit http://www.genomics.cn
Contact Information
Bicheng Yang, Ph.D. Public Communication Officer BGI +86-755-82639701 yangbicheng@genomics.cn http://www.genomics.cn
Journal
Nature Genetics