Earphones 'potentially as dangerous as noise from jet engines,' according to new study

Turning the volume up too high on your headphones can damage the coating of nerve cells, leading to temporary deafness; scientists from the University of Leicester have shown for the first time.

Earphones or headphones on personal music players can reach noise levels similar to those of jet engines, the researchers said.

Noises louder than 110 decibels are known to cause hearing problems such as temporary deafness and tinnitus (ringing in the ears), but the University of Leicester study is the first time the underlying cell damage has been observed.

The study has been published in the Proceedings of the National Academy of Sciences.

University of Leicester researcher Dr Martine Hamann of the Department of Cell Physiology and Pharmacology, who led the study, said:

"The research allows us to understand the pathway from exposure to loud noises to hearing loss. Dissecting the cellular mechanisms underlying this condition is likely to bring a very significant healthcare benefit to a wide population. The work will help prevention as well as progression into finding appropriate cures for hearing loss."

Nerve cells that carry electrical signals from the ears to the brain have a coating called the myelin sheath, which helps the electrical signals travel along the cell. Exposure to loud noises - i.e. noise over 110 decibels - can strip the cells of this coating, disrupting the electrical signals. This means the nerves can no longer efficiently transmit information from the ears to the brain.

However, the coating surrounding the nerve cells can reform, letting the cells function again as normal. This means hearing loss can be temporary, and full hearing can return, the researchers said.

Dr Hamann explained: "We now understand why hearing loss can be reversible in certain cases. We showed that the sheath around the auditory nerve is lost in about half of the cells we looked at, a bit like stripping the electrical cable linking an amplifier to the loudspeaker. The effect is reversible and after three months, hearing has recovered and so has the sheath around the auditory nerve."

The findings are part of ongoing research into the effects of loud noises on a part of the brain called the dorsal cochlear nucleus, the relay that carries signals from nerve cells in the ear to the parts of the brain that decode and make sense of sounds. The team has already shown that damage to cells in this area can cause tinnitus - the sensation of 'phantom sounds' such as buzzing or ringing.

The research was funded by the Wellcome Trust, Medisearch, GlaxoSmithkline and the Royal Society.

Notes for editors:

For more information contact: Martine Hamann, email: mh86@le.ac.uk

PNAS reference: Mechanisms contributing to central excitability changes during hearing loss. Pilati N, Ison MJ, Barker M, Mulheran M, Large CH, Forsythe ID, Matthias J, Hamann M.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8292-7. Epub 2012 May 7

The research was funded by Wellcome Trust, Medisearch (running costs), GlaxoSmithkline (PhD studentship for Nadia Pilati), Royal Society (equipment grant).

• Nadia Pilati (CPP Dept) performed all the electrophysiological experiments.
• Matt Barker (CPP Dept) performed the electron microscopy experiments in collaboration with the electron microscopy suite here in Leicester.
• Mike Mulheran (Medical Education Dept) helped us with the auditory brainstem response recordings (to assess hearing loss).
• Matias Ison (Engineering Dept) performed the modelling using Matlab. His modelling guided us into exploring the possibility of the sheath being affected during hearing loss.
• John Mathias (University of Plymouth) and Matias Ison generated the sound file that can be downloaded from the PNAS paper.

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