CHICAGO – Immunotherapy with the antibody bapineuzumab in patients with mild to moderate Alzheimer disease resulted in decreases in a cerebrospinal fluid biomarker, which may indicate downstream effects on the degenerative process, according to a report published Online First by Archives of Neurology, a JAMA Network publication.
Alzheimer disease (AD) is a progressive neurodegenerative disease characterized by, among other things, deposits of extracellular β-amyloid (Αβ) plaques and intraneuronal neurofibrillary tangles with accompanying decreases in cerebrospinal fluid (CSF) Αβ and increases in CSF tau proteins. Bapineuzumab is an anti-Αβ monoclonal antibody, and immunotherapy with antibodies against Αβ is one of the major disease-modifying therapeutic approaches being evaluated for AD, the authors write in their study background.
Kaj Blennow, M.D., Ph.D., of the University of Gothenburg, Sweden, and colleagues conducted a combined analysis of two double-blind, placebo-controlled trials that included 46 patients with mild to moderate AD. A total of 27 patients were treated with bapineuzumab and 19 with placebo. The researchers evaluated whether bapineuzumab affected the CSF levels of the downstream biomarkers, total tau (T-tau) and phosphorylated tau (P-tau), and the primary biomarker Αβ in the completed trials.
"The reduction in the downstream biomarker CSF P-tau following treatment with bapineuzumab suggests that bapineuzumab reduces brain levels of P-tau, which may also reduce the formation of tangles in the brain," the authors note.
Although there was a reduction in CSF T-tau, it did not reach statistical significance compared with placebo. No clear-cut differences were observed for CSF Αβ, the study results indicate. But the observed decrease in both P-tau and T-tau require further examination, the authors note.
"An important question remains whether such changes in CSF biomarkers correlate with clinical benefit. This question will be addressed in the ongoing bapineuzumab phase 3 trials," the authors conclude.
(Arch Neurol. Published online April 2, 2012. doi:10.1001/archneurol.2012.90. Available pre-embargo to the media at www.jamamedia.org.)
Editor's Note: The authors made numerous financial disclosures including of employment. The study was funded by Elan (acquired by Janssen Alzheimer Immunotherapy in 2009) and Wyeth Pharmaceuticals (acquired by Pfizer in 2009). Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
To contact Kaj Blennow, M.D., Ph.D., email kaj.blennow@neuro.gu.se.
Journal
Archives of Neurology