USPSTF releases new guidelines for cervical cancer screening

Philadelphia, March 15, 2012 – Women ages 21 to 65 should have a Pap smear every three years, according to new guidelines from the United States Preventive Services Task Force (USPSTF). Based on the evidence, women between the ages of 30 and 65 can safely extend the screening interval to once every five years if they undergo the humanpapillomavirus (HPV) test at the same time as the Pap. The guideline is being published early online in Annals of Internal Medicine.

The USPSTF recommends against screening for cervical cancer in women younger than 21, as there is adequate evidence that screening in this population, regardless of sexual history, provides no reduction in cervical cancer incidence and mortality. Women older than 65 who have had adequate prior screening and are not otherwise at high risk also do not need screening.

"This is good news for women because evidence shows that an annual Pap smear is not necessary to prevent deaths from cervical cancer," said Task Force Chair, Virginia Moyer, MD, MPH, Professor of Pediatrics, Baylor Medical College. "Screening every three years starting at age 21 saves the same number of lives as annual screening, but with half the number of colposcopies and fewer false-positive tests."

Since releasing a draft recommendation in October 2011, new evidence became available about the role of HPV testing in cervical cancer screening. The Task Force reviewed the evidence and now recommends HPV screening in combination with the Pap for women aged 30 and 65. If HPV testing is done at the same time as the Pap, women can extend their screening interval to five years. The Task Force does not recommend HPV screening in women under the age of 30, as the infection is prevalent in younger women and often clears up on its own.

According to the Center for Disease Control and Prevention, women aged 30 years old and older who have had a normal Pap result have a very low chance of getting cervical cancer in the next few years. This information supports the wisdom of extended screening intervals for cervical cancer. However, women should not skip regular check-ups.

According to the Task Force guidelines, women who have had a hysterectomy with removal of the cervix and who do not have a history of cervical cancer or a high-grade precancerous lesion do not need to be screened. In this population, there is high certainty that harms of screening outweigh the benefits.

Women over the age of 65 can end screening if they have had three consecutive negative Pap smears or two consecutive negative co-tests within 10 years before cessation of screening, with the last test occurring within five years. Routine screening should continue at least 20 years after spontaneous regression or appropriate management of high-grade precancerous lesion, regardless of the patient's age. Physicians should consider cervical cancer screening in women over the age of 65 who have never been screened.

Full text of the guidelines are available free to the public at www.annals.org.

Annals of Internal Medicine is one of the five most widely cited peer-reviewed medical journals in the world, with a current impact factor of 16.7. The journal has been published for 85 years. It accepts only 7 percent of the original research studies submitted for publication. Follow Annals on Twitter and Facebook.