Hepatocellular carcinoma (HCC) responds poorly to chemotherapy owing to MDR. Recent studies have shown the tumors derived from the colon, kidney, or adrenal cortex, and HCC exhibited overexpression of MDR1/P-gp. This overexpression results in a primary MDR phenotype of these cancers. Tumor derived cell lines are one of the most important tools for investigation of the biological mechanisms directly leading to drug resistance in patients. Today, the experimental search for drug resistant mechanisms that are clinically relevant targets whose circumvention can improve cancer therapy is still ongoing.
A research, lead by Professor Ling and his colleagues in the Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, has recently been published on May 14, 2010 in the World Journal of Gastroenterology, to represent models for investigating MDR in human HCC. Analysis of novel chemotherapy-resistant cell lines may duplicate the treatment conditions used in vivo.
The new MDR cell line, SK-Hep1/CDDP, can be used as an in vitro model to elucidate the biological mechanisms of MDR in hepatoma, from delineating the process of carcinogenesis through to testing new therapeutic agents. SK-Hep1/CDDP cells can also be used to explore targeted approaches for improving MDR cancer therapy.
Reference: Zhou Y, Ling XL, Li SW, Li XQ, Yan B. Establishment of a human hepatoma multidrug resistant cell line in vitro. World J Gastroenterol 2010; 16(18): 2291-2297 http://www.wjgnet.com/1007-9327/full/v16/i18/2291.htm
Correspondence to: Xian-Long Ling, Professor, Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. lingxlong@yahoo.com.cn Telephone: +86-23-68774204 Fax: +86-23-68755604
About World Journal of Gastroenterology
World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2008 IF: 2.081. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.
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World Journal of Gastroenterology