Avian influenza (H5N1) outbreaks in Europe during the winter of 2005-2006 occurred at the edge of cold weather fronts, according to researchers from Princeton University and the Erasmus Medical Centre, Rotterdam, the Netherlands. Their results, published April 8 in the open-access journal PLoS Pathogens, show that these outbreaks were driven by aggregated movements of wild waterbirds away from areas of frozen water.
The researchers found that most H5N1 outbreaks occurred at sites where maximum temperatures were between 0°C and 2°C. These usually occurred on the edge of cold fronts where bodies of freshwater remained unfrozen. Many wild waterbirds need unfrozen bodies of freshwater in winter to feed; in order to minimize the distance flown, they also try to stay as close as possible to the northern breeding grounds to which they will migrate during spring. The resulting congregation of different species of waterbirds along the freezing front likely created ideal conditions for the transmission of the H5N1 virus within and between wild bird species; in 2006, it caused many detectable outbreaks.
The genetic tree of the H5N1 virus that caused outbreaks in Europe is well known. However, the conditions favoring the virus' spread were previously unclear. Understanding these ecological links may help to predict and control future outbreaks.
Forecasts predicting near-freezing temperatures in Europe may act as an indication for concern, the authors say. When these conditions are forecasted, the authors suggest that targeted surveillance in areas along the extreme edge of cold fronts may help in the early detection of the virus.
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FINANCIAL DISCLOSURE: The present study was supported in part by European Commission grant no. 044490 ''New-FluBird''. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
COMPETING INTERESTS: The authors have declared that no competing interests exist.
PLEASE ADD THIS LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.plos.org/10.1371/journal.ppat.1000854 (link will go live upon embargo lift)
CITATION: Reperant LA, Fučkar NS, Osterhaus ADME, Dobson AP, Kuiken T (2010) Spatial and Temporal Association of Outbreaks of H5N1 Influenza Virus Infection in Wild Birds with the 0uC Isotherm. PLoS Pathog 6(4): e1000854. doi:10.1371/journal.ppat.1000854
CONTACT:
Leslie Reperant
Department of Ecology and Evolutionary Biology
Princeton University
tel: 609 751 3610
email: reperant@princeton.edu
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