Enhancing the effects of the brain chemical dopamine influences how people make life choices by affecting expectations of pleasure, according to new research from the UCL Institute of Neurology.
The study, published today in Current Biology, confirms an important role for dopamine in how human expectations are formed and how people make complex decisions. It also contributes to an understanding of how pleasure expectation can go awry, for example in drug addiction.
Dopamine is a neurotransmitter produced in several areas of the brain that is found in a wide variety of animals. Its role in reward learning and reward-seeking behaviour is well established by animal studies – however, in humans its role is much less understood.
Lead author Dr Tali Sharot, Wellcome Trust Centre for Neuroimaging at UCL, said: "Humans make much more complex decisions than other animals – such as which job to take, where to go on holiday, whether to start a family – and we wanted to understand the role of dopamine in making these types of decisions. Our results indicate that when we consider alternative options when making real-life decisions, dopamine has a role in signalling the expected pleasure from those possible future events. We then use that signal to make our choices."
The research team, which included Dr Tamara Shiner and Professor Ray Dolan, examined estimated pleasure of future events before and after the administration of a drug called L-DOPA which is known to enhance dopamine function in the brain and is commonly used to treat patients with Parkinson's disease. The 61 study participants were asked to rate their expectations of happiness if they were to holiday at each of 80 destinations, from Thailand to Greece. They were then given L-DOPA or a placebo and asked to imagine holidaying in those destinations.
The following day participants had to pick between a series of paired destinations that they had initially assigned with equal ratings, one member of the pair was imagined under L-DOPA the day before and the other under placebo. Finally, they rated the full set of 80 destinations again.
Ratings for particular destinations increased after they were imagined under L-DOPA's influence. That increase also affected the participants' selections the following day. Dr Sharot added: "We had reason to believe that dopamine would enhance expectations of pleasure in humans, but were surprised at the strength of this effect. The enhancement lasted at least 24 hours and was evident in almost 80 per cent of the subjects."
The study builds on earlier work by Dr Sharot and colleagues, which used brain imaging as participants imagined holiday destinations. An area of the brain called the straitum tracked expectations and the scientists found that they could take that signal and predict what the participants would choose. The authors believed this was dopamine at work and set-up this study to further explore its role.
Notes for Editors
1.) For more information, or to interview the UCL researchers quoted, please contact Ruth Howells in the UCL Media Relations Office on tel: +44 (0)20 7679 9739, mobile: +44 (0)7990 675 947, out of hours +44 (0)7917 271 364, e-mail: ruth.howells@ucl.ac.uk
2.) The paper 'Dopamine enhances expectation of pleasure in humans' is published online ahead of print in Current Biology, embargoed until Thursday 12th November 2009 at 1700 GMT (1200 Eastern Time). For copies of the paper, please contact Cathleen Genova in the Cell Press Office on tel: +1-617-397-2802, email: cgenova@cell.com
3.) This research was supported by the Wellcome Trust, the British Academy and the Medical Research Council.
About UCL
Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender, and the first to provide systematic teaching of law, architecture and medicine. UCL is the third-ranked university in the 2009 THES-QS World University Rankings, and the fourth-ranked UK university in the 2009 league table of the top 500 world universities produced by the Shanghai Jiao Tong University. UCL alumni include Marie Stopes, Jonathan Dimbleby, Lord Woolf, Alexander Graham Bell, and members of the band Coldplay. UCL currently has over 12,000 undergraduate and 8,000 postgraduate students. Its annual income is over £600 million.
Journal
Current Biology