image: The gene networks illustrated in "Pathways to Discovery: Autoimmune Diseases" promise to facilitate the discovery of targeted therapies for many autoimmune diseases. view more
Credit: The Jackson Laboratory
Bar Harbor, Maine - Currently, 5-8% of the U.S. population is afflicted with an autoimmune disease (www.niaid.nih.gov). Many of these are chronic and require life-long care. Moreover, different autoimmune diseases aggregate within a single family, suggesting they are caused by disruptions in common biological pathways.
To help researchers investigate these common pathways, The Jackson Laboratory has published "Pathways to Discovery: Autoimmune Diseases" (www.jax.org/jaxmice/pathways/autoimmune), a unique, interactive, and publicly accessible online resource that illustrates the genetic networks involved in five common autoimmune diseases: inflammatory bowel disease, rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis.
The backbone of the new tool is five "spider-web" diagrams that depict the gene/proteins involved in two or more of the five diseases. The symbols in the diagrams represent cytokines, transmembrane receptors, enzymes, nuclear receptors, and transcriptional regulators. The resource also provides gene- and disease-specific references, links to JAX® Mice strains (including inducible mouse models) that can be used to research the five diseases, and descriptions of JAX® In Vivo Services for compound efficacy testing.
"Pathways to Discovery: Autoimmune Diseases" promises to accelerate the discovery of autoimmune disease mechanisms and therapeutic interventions for both new and existing targets. Check it out today at www.jax.org/jaxmice/pathways/autoimmune.
For more information or a brief tour of this new tool, contact JAX Technical Information Services at 1-800-422-6423, or your Jackson Laboratory regional representative (contact information at www.jax.org/jaxmice/support/regionalcontacts).